Impact of depressive symptoms on subjective well-being: the importance of patient-reported outcomes in schizophrenia
نویسندگان
چکیده
OBJECTIVE The subjective experience of psychotic patients toward treatment is a key factor in medication adherence, quality of life, and clinical outcome. The aim of this study was to assess the subjective well-being in patients with schizophrenia and to examine its relationship with the presence and severity of depressive symptoms. METHODS A multicenter, cross-sectional study was conducted with clinically stable outpatients diagnosed with schizophrenia. The Subjective Well-Being under Neuroleptic Scale - short version (SWN-K) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to gather information on well-being and the presence and severity of depressive symptoms, respectively. Spearman's rank correlation was used to assess the associations between the SWN-K total score, its five subscales, and the CDSS total score. Discriminative validity was evaluated against that criterion by analysing the area under the curve (AUC). RESULTS Ninety-seven patients were included in the study. Mean age was 35 years (standard deviation = 10) and 72% were male. Both the total SWN-K scale and its five subscales correlated inversely and significantly with the CDSS total score (P < 0.0001). The highest correlation was observed for the total SWN-K (Spearman's rank order correlation [rho] = -0.59), being the other correlations: mental functioning (-0.47), social integration (-0.46), emotional regulation (-0.51), physical functioning (-0.48), and self-control (-0.41). A total of 33 patients (34%) were classified as depressed. Total SWN-K showed the highest AUC when discriminating between depressive severity levels (0.84), followed by emotional regulation (0.80), social integration (0.78), physical functioning and self-control (0.77), and mental functioning (0.73). Total SWN-K and its five subscales showed a significant linear trend against CDSS severity levels (P < 0.001). CONCLUSION The presence of moderate to severe depressive symptoms was relatively high, and correlated inversely with patients' subjective well-being. Routine assessment of patient-reported measures in patients with schizophrenia might reduce potential discrepancy between patient and physician assessment, increase therapeutic alliance, and improve outcome.
منابع مشابه
Association between subjective well-being and depressive symptoms in treatment-resistant schizophrenia before and after treatment with clozapine.
BACKGROUND We examined the relationship between subjective well-being and depressive symptoms in patients with treatment-resistant schizophrenia before and after treatment with clozapine to contribute to the growing body of research regarding the determinants of patients' perspective of their own well-being in schizophrenia. METHODS Forty patients with treatment-resistant schizophrenia were c...
متن کاملThe relationship between depressive symptoms and subjective well-being in newly admitted patients with schizophrenia.
BACKGROUND Depressive symptoms are common in schizophrenia and are considered core features of the disorder. The purpose of the present study was to examine the relationship between depressive symptoms and subjective well-being in newly admitted patients with schizophrenia. METHODS Eighty newly admitted patients were comprehensively evaluated for subjective well-being, schizophrenic symptoms,...
متن کاملAnalysis of the effectiveness of communities on the children subjective well-being at sixth region of Tehran
Back ground: The main purpose of this research is to analyze the impact of communities on the subjective well-being of children aged 10 to 12 years in the sixth region of Tehran. The research based on the division of Diner's approaches has been calculated from the factors affecting subjective well-being and the dimensions of the pleasurable welfare of Reese. The theory of spatial systems, Bruff...
متن کاملAnalysis of the effectiveness of communities on the children subjective well-being at sixth region of Tehran
Back ground: The main purpose of this research is to analyze the impact of communities on the subjective well-being of children aged 10 to 12 years in the sixth region of Tehran. The research based on the division of Diner's approaches has been calculated from the factors affecting subjective well-being and the dimensions of the pleasurable welfare of Reese. The theory of spatial systems, Bruff...
متن کاملEfficacy of Risperidone Augmentation with Ondansetron in the Treatment of Negative and Depressive Symptoms in Schizophrenia: A Randomized Clinical Trial
Background: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia.Methods: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in ...
متن کامل